MEREDITH: Stop crying. Look, it took me a long time to find him. A long time. And even then it took me a long time to even know that I wanted him. To be married. To be his wife. To have his kids. And now that I realize that, he’s lying on a table in there and my best friend’s hands are inside his chest. You don’t get to cry about that.
APRIL: Reed was my best friend. She died today.
[Meredith holds her hand out, April grabs it]
Grey’s Anatomy, 6×24 Death and All His Friends